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KMID : 0363320010220020119
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Journal of Korean Oriental Internal Medicine
2001 Volume.22 No. 2 p.119 ~ p.125
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Studies on the Effect and Mechanism of Geupoongjibo-dan’s Relaxation on a Blood Vessel
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Han Sung-Ho
Kim Dong-Eun
Park DOng-Wan
Jeong Seung-Hyun
Shin Gil-Cho
Lee Won-Chul
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Abstract
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Objectives : This study was conducted to evaluate the effect and mechanism of Geupoongjibo-dan’s relaxation of the tension of the blood vessel caused by Phenylephrine and KCI.
Methods : In order to study the effect of Geupoongjibo-dan’s relaxation of the blood vessel tension, Geupoongjibo-dan extract was infused into Phenylephrine and KCI-induced contracted rabbit aorta strips. To analyze the mechanism of Geupoongjibo-dan’s effect on the blood vessel, Geupoongjibo-dan extract infused into Phenylephrine and KCI-induced contracted strips induced by agonists after treatment of N{omega}-nitro-L-arginine, Methylene Blue.
Results :
1. Geupoongjibo-dan was very effective in relaxing the blood vessels contracted by Phenylephrine.
2. Geupoongjibo-dan was effective against Phenylephrine, than against KCI.
3. Geupoongjibo-dan’s more relaxation effect on a blood vessel was terminated by N{omega}-nitro-L-arginine and methylene treatment.
Conclusion : THis study showed that Geupoongjibo-dan’s relaxation effect on a blood vessel is irrelevant to {alpha}-adrenalin receptor, and it relaxes contracted vessels through cGMP channel.
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KEYWORD
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Geupoongjibo-dan extract, relaxation effect, blood vessel’s tension
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